Certified Clinical Research Associate (CCRA) Practice Exam 2025 – Complete Preparation Guide

The typical percentage that sponsors may withhold until the completion of a study is often around 10% or greater. This practice serves several purposes, including ensuring that the site meets certain performance metrics before receiving full compensation. Withholding a portion of funds can also serve as an incentive for sites to adhere to protocols, timely data submission, and patient enrollment goals.

By implementing this withholding strategy, sponsors can maintain leverage over site performance throughout the study duration, promoting accountability and encouraging compliance with study requirements. This practice also reflects the financial dynamics of clinical trials, where sponsors want to safeguard their investments until they are assured of the project's successful completion and regulatory compliance.

While some sponsors may vary their withholding strategies based on the specifics of their agreements or the nature of the study, the 10% threshold is not uncommon in clinical trial agreements.